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The influence of lack of reference conditions on dosimetry in pre-clinical radiotherapy with medium energy x-ray beams

Subiel, Anna, Silvestre Patallo, Ileana, Palmans, Hugo, Barry, Miriam, Tulk, Amanda, Soultanidis, Georgios, Greenman, John, Green, Victoria L, Cawthorne, Christopher and Schettino, Giuseppe (2020) The influence of lack of reference conditions on dosimetry in pre-clinical radiotherapy with medium energy x-ray beams Physics in Medicine & Biology, 65 (8), 085016.

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Despite well-established dosimetry in clinical radiotherapy, dose measurements in pre-clinical and radiobiology studies are frequently inadequate, thus undermining the reliability and reproducibility of published findings. The lack of suitable dosimetry protocols, coupled with the increasing complexity of pre-clinical irradiation platforms, undermines confidence in preclinical studies and represents a serious obstacle in the translation to clinical practice. To accurately measure output of a pre-clinical radiotherapy unit, appropriate Codes of Practice (CoP) for medium energy x-rays needs to be employed. However, determination of absorbed dose to water (Dw) relies on application of backscatter factor (Bw) employing in-air method or carrying out in-phantom measurement at the reference depth of 2 cm in a full backscatter (i.e. 30 × 30 × 30 cm3) condition. Both of these methods require thickness of at least 30 cm of underlying material, which are never fulfilled in typical pre-clinical irradiations. This work is focused on evaluation the effects of the lack of recommended reference conditions in dosimetry measurements for pre-clinical settings and is aimed at extending the recommendations of the current CoP to practical experimental conditions and highlighting the potential impact of the lack of correct backscatter considerations on radiobiological studies.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Subiel, Anna
Silvestre Patallo, Ileana
Palmans, Hugo
Barry, Miriam
Tulk, Amanda
Soultanidis, Georgios
Greenman, John
Green, Victoria L
Cawthorne, Christopher
Date : 23 April 2020
Funders : Innovate UK
DOI : 10.1088/1361-6560/ab7b30
Grant Title : Innovate UK Grant
Copyright Disclaimer : © 2020 Institute of Physics and Engineering in Medicine
Additional Information : Embargo OK Metadata OK
Depositing User : James Marshall
Date Deposited : 25 Aug 2020 15:50
Last Modified : 25 Aug 2020 15:50

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