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An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic

Price, Gareth, Biglin, Emma R, Collins, Sean, Aitkinhead, Adam, Subiel, Anna, Chadwick, Amy L, Cullen, David, M, Kirkby, Karen J, Schettino, Giuseppe, Tipping, Jill and Robinson, Andrew (2020) An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic Physics in Medicine & Biology, 65 (10), 10NT02.

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The lack of rigorous quality standards in pre-clinical radiation dosimetry has renewed interest in the development of anthropomorphic phantoms. Using 3D printing customisable phantoms can be created to assess all parts of pre-clinical radiation research: planning, image guidance and treatment delivery. We present the full methodology, including material development and printing designs, for the production of a high spatial resolution, anatomically realistic heterogeneous small animal phantom. A methodology for creating and validating tissue equivalent materials is presented. The technique is demonstrated through the development of a bone-equivalent material. This material is used together with a soft-tissue mimicking ABS plastic filament to reproduce the corresponding structure geometries captured from a CT scan of a nude mouse. Air gaps are used to represent the lungs. Phantom validation was performed through comparison of the geometry and x-ray attenuation of CT images of the phantom and animal images. A 6.6% difference in the attenuation of the bone-equivalent material compared to the reference standard in softer beams (0.5 mm Cu HVL) rapidly decreases as the beam is hardened. CT imaging shows accurate (sub-millimetre) reproduction of the skeleton (Distance-To-Agreement 0.5 mm ± 0.4 mm) and body surface (0.7 mm ± 0.5 mm). Histograms of the voxel intensity profile of the phantom demonstrate suitable similarity to those of both the original mouse image and that of a different animal. We present an approach for the efficient production of an anthropomorphic phantom suitable for the quality assurance of pre-clinical radiotherapy. Our design and full methodology are provided as open source to encourage the pre-clinical radiobiology community to adopt a common QA standard.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Price, Gareth
Biglin, Emma R
Collins, Sean
Aitkinhead, Adam
Subiel, Anna
Chadwick, Amy L
Cullen, David, M
Kirkby, Karen J
Tipping, Jill
Robinson, Andrew
Date : 29 May 2020
Funders : NC3Rs, Cancer Research UK - Cancer Research Manchester Centre, STFC-IAA
DOI : 10.1088/1361-6560/ab8078
Grant Title : NC3Rs
Copyright Disclaimer : © 2020 Institute of Physics and Engineering in Medicine
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 25 Aug 2020 15:36
Last Modified : 25 Aug 2020 15:36

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