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Radiobiological Implications of Nanoparticles Following Radiation Treatment

Ahmad, Reem, Schettino, Giuseppe, Royle, Gary, Barry, Miriam, Pankhurst, Quentin A., Tillement, Olivier, Russell, Ben and Ricketts, Kate (2020) Radiobiological Implications of Nanoparticles Following Radiation Treatment Particle & Particle Systems Characterization, 37 (4), 1900411.

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Materials with a high atomic number (Z) are shown to cause an increase in the level of cell kill by ionizing radiation when introduced into tumor cells. This study uses in vitro experiments to investigate the differences in radiosensitization between two cell lines (MCF‐7 and U87) and three commercially available nanoparticles (gold, gadolinium, and iron oxide) irradiated by 6 MV X‐rays. To assess cell survival, clonogenic assays are carried out for all variables considered, with a concentration of 0.5 mg mL−1 for each nanoparticle material used. This study demonstrates differences in cell survival between nanoparticles and cell line. U87 shows the greatest enhancement with gadolinium nanoparticles (2.02 ± 0.36), whereas MCF‐7 cells have higher enhancement with gold nanoparticles (1.74 ± 0.08). Mass spectrometry, however, shows highest elemental uptake with iron oxide and U87 cells with 4.95 ± 0.82 pg of iron oxide per cell. A complex relationship between cellular elemental uptake is demonstrated, highlighting an inverse correlation with the enhancement, but a positive relation with DNA damage when comparing the same nanoparticle between the two cell lines

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Ahmad, Reem
Royle, Gary
Barry, Miriam
Pankhurst, Quentin A.
Tillement, Olivier
Russell, Ben
Ricketts, Kate
Date : 3 March 2020
Funders : Medical Research Council Proximity to Discovery, Peter Samuel Royal Free Fund
DOI : 10.1002/ppsc.201900411
Grant Title : Medical Research Council Proximity to Discovery
Copyright Disclaimer : © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 25 Aug 2020 15:21
Last Modified : 25 Aug 2020 15:21

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