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Maternal Vitamin D Supplementation inhibits Bisphenol A-induced proliferation of Th17 cells in adult offspring

Wang, Gengfu, Li, Yingpei, Li, Yun, Zhang, Jiaxiang, Zhou, Chengfan, Wu, Changhao, Zhu, Qixing and Shen, Tong (2020) Maternal Vitamin D Supplementation inhibits Bisphenol A-induced proliferation of Th17 cells in adult offspring Food and Chemical Toxicology, 111604.

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Bisphenol A (BPA) exposure can increase the risk of immune-related diseases in later life. Vitamin D3 (Vit D3) has been shown to have multiple immunomodulatory actions and has been used to treat immune diseases. However, the potential beneficial effects of Vit D3 on BPA-induced adverse effects in the immune system have not explored. We hypothesize that VitD3 may ameliorate BPA-induced side effects in the immune system, even in offspring of VitD3-supplemented mothers. Here, we established our experimental model by exposing pregnant dams with 1000 nM BPA with or without VitD3 (0.25 μg/kg, 1 μg/kg and 4 μg/kg) treatment. We show that mother’s exposure to BPA increases proliferation of the spleen T helper 17 (Th17) cells and serum protein level of IL-17 in the offspring; however, VitD3 supplementation in mothers dose-dependently ameliorated these BPA-induced side effects on the immune system in the offspring as evidenced by attenuated upregulation of Th17 proliferation, and RORγt, IL-17, IL-6, and IL-23 expressions in the offspring. Our data provide the first evidence that maternal VitD3 supplementation offers benefits to the offspring by attenuating BPA-induced side effects on the immune system through vitamin D receptor (VDR)-dependent regulation of transcription factors and cytokines, suggesting its translational potential.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Wang, Gengfu
Li, Yingpei
Li, Yun
Zhang, Jiaxiang
Zhou, Chengfan
Zhu, Qixing
Shen, Tong
Date : 20 July 2020
Funders : Biotechnology and Biological Sciences Research Council (BBSRC)
DOI : 10.1016/j.fct.2020.111604
Copyright Disclaimer : © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Vitamin D3; Bisphenol A; Th17 cells; VDR; RORγt; Endocrine disrupting chemical
Depositing User : Clive Harris
Date Deposited : 03 Aug 2020 10:40
Last Modified : 03 Aug 2020 10:40

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