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Very High Prevalence of 25-hydroxyvitamin D Deficiency in n 6433 UK South Asian adults: analysis of the UK Biobank Cohort

Darling, Andrea L., Blackbourn, David J., Ahmadi, Kourosh R. and Lanham-New, Susan A. (2020) Very High Prevalence of 25-hydroxyvitamin D Deficiency in n 6433 UK South Asian adults: analysis of the UK Biobank Cohort British Journal of Nutrition. pp. 1-34.

Vitamin D deficiency in Biobank South Asians__forSRI_22-7-20.pdf - Accepted version Manuscript

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Little research has assessed serum 25-hydroxyvitamin D (25(OH)D) concentration and its predictors in western dwelling South Asians in a relatively large sample size. This observational, cross-sectional analysis assessed baseline prevalence of 25(OH)D deficiency in UK dwelling South Asians (aged 40-69 years, 2006-2010) from the UK Biobank cohort. Serum 25(OH)D measurements were undertaken using the DiaSorin Liaison XL assay. Of n 6433 South Asians with a 25(OH)D measurement, using commonly used cut-off thresholds, 55% (n 3538) had 25(OH)D <25 nmol/L (severe deficiency) and 92% (n 5918) had 25(OH)D <50 nmol/L (insufficiency). Twenty per cent (n 1287) had 25(OH)D concentration <15 nmol/L (very severe deficiency). When n 824 participants with undetectable (<10 nmol/L) 25(OH)D measurements were included (total n 7257), 29% (n 2105) had 25(OH)D <15 nmol/L, 60% (n 4354) had 25(OH)D <25 nmol/L and 93% (n 6749) had 25(OH)D < 50 nmol/L. Logistic regression predictors of 25(OH)D <25 nmol/L included the following characteristics: being male; Pakistani; higher body mass index; 40-59 years old; never consuming oily fish; summer sun exposure < 5 hours per day, not using a vitamin D containing supplement, measurement in winter or spring and vegetarianism. In terms of region, median 25(OH)D concentration was 19-20 nmol/L in Scotland, Northern England, the Midlands and Wales. Across Southern England and London it was slightly higher at 24-25 nmol/L. Our analyses suggest the need for increased awareness of vitamin D deficiency in South Asians as well as urgent public health interventions to prevent and treat vitamin D deficiency in this group.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Darling, Andrea
Blackbourn, David
Ahmadi, Kourosh
Lanham-New, Susan
Date : 22 July 2020
Funders : UK Biobank Resource, Wellcome Trust Medical Charity, Medical Research Council, Department of Health, Scottish Government, Northwest Regional Development Agency, Welsh Assembly Government, British Heart Foundation
DOI : 10.1017/S0007114520002779
Grant Title : UK Biobank Resource
Copyright Disclaimer : © The Authors 2020
Uncontrolled Keywords : 25-hydroxyvitamin D, Ethnicity, Epidemiology, Cohort
Additional Information : Embargo OK Metadata Pending Accepted version is published online, but is not final version.
Depositing User : James Marshall
Date Deposited : 22 Jul 2020 09:09
Last Modified : 22 Jul 2020 09:09

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