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Flow behaviour of pharmaceutical powders during rotary die filling with a paddle feeder

Tang, Xue, Zakhvatayeva, Anastasiya, Zhang, Ling, Wu, Zhen-Feng, Sun, Ping and Wu, Chuan-Yu (2020) Flow behaviour of pharmaceutical powders during rotary die filling with a paddle feeder International Journal of Pharmaceutics, 585, 119547.

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Rotary tabletting presses are widely used to produce tablets in the pharmaceutical industry. In the tabletting process using a rotary press, rotary die filling is one of critical process steps, as powder behaviour during die filling dictates the quality of final products, such as dosage and weight variations. It is hence of importance to understand powder flow behaviour during rotary die filling. The purpose of this study is to identify the critical process parameters and material attributes that determine the die filling performance. For this purpose, a model rotary die filling system with a paddle feeder was constructed to mimic the powder feeding process in a typical rotary press. Using this model system, the effects of turret speed and paddle speed on die filling behaviour were investigated. Three grades of microcrystalline cellulose powders were considered. It was found that the turret speed has a more pivotal role in controlling the die filling performance than the paddle speed. In addition, it is demonstrated that powder flowability has a great impact on the fill weight variation, and a higher weight variation is induced for the powders with poorer flowability.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Tang, Xue
Zakhvatayeva, Anastasiya
Wu, Zhen-Feng
Sun, Ping
Wu, Chuan-Yu
Date : 12 June 2020
Funders : International Fine Particle Research Institute (IFPRI), Jiangxi University of Traditional Chinese Medicine Graduates Overseas Scholar Visiting Funding Programme
DOI : 10.1016/j.ijpharm.2020.119547
Copyright Disclaimer : © 2020 Elsevier B.V. All rights reserved.
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 17 Jul 2020 14:46
Last Modified : 17 Jul 2020 14:46

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