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Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness

Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christina, Brandewinder, Marie , Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N., Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M. and Vandewalle, Gilles (2020) Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness Sleep.

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Muto_Sleep_preprint_medrxiv-1.pdf - Accepted version Manuscript
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Study Objectives. Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. Methods. We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation and extended sleep opportunity, in a carefully selected homogenous sample of healthy 363 young men (22.1 y ± 2.7) devoid of sleep and cognitive disorders. Results. AD PRS was associated with more slow wave energy, i.e. the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with large slow wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness. Conclusions. These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Muto, Vincenzo
Koshmanova, Ekaterina
Ghaemmaghami, Pouya
Jaspar, Mathieu
Meyer, Christelle
Elansary, Mahmoud
Van Egroo, Maxime
Chylinski, Daphne
Berthomier, Christina
Brandewinder, Marie
Mouraux, Charlotte
Schmidt, Christina
Hammad, Gregory
Coppieters, Wouter
Ahariz, Naima
Degueldre, Christian
Luxen, Andre
Salmon, Eric
Phillips, Christophe
Archer, Simon N.
Yengo, Loic
Byrne, Enda
Collette, Fabienne
Georges, Michel
Maquet, Pierre
Visscher, Peter M.
Vandewalle, Gilles
Date : 8 July 2020
Funders : Fonds de la Recherche Scientifique - FNRS-Belgium., Wallonia-Brussels Federation, FNRS-Belgium, University of Liège, European Regional Development Fund, UK Dementia Research Institute
Grant Title : Wallonia-Brussels Federation
Additional Information : Embargo OK Metadata Pending
Depositing User : James Marshall
Date Deposited : 15 Jul 2020 09:25
Last Modified : 15 Jul 2020 09:25

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