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Anisotropic light scattering of individual sickle red blood cells

Kim, Youngchan, Higgins, John M., Dasari, Ramachandra R., Suresh, Subra and Park, YongKeun (2012) Anisotropic light scattering of individual sickle red blood cells Journal of Biomedical Optics, 17 (4), 040501.

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We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Higgins, John M.
Dasari, Ramachandra R.
Suresh, Subra
Park, YongKeun
Date : 5 April 2012
DOI : 10.1117/1.JBO.17.4.040501
Depositing User : James Marshall
Date Deposited : 29 Jun 2020 12:58
Last Modified : 29 Jun 2020 12:58

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