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Non-24-Hour Sleep-Wake Syndrome in Sighted and Blind Patients

Uchiyama, M. and Lockley, S.W. (2009) Non-24-Hour Sleep-Wake Syndrome in Sighted and Blind Patients Sleep Medicine Clinics, 4 (2). pp. 195-211.

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Non-24-hour sleep-wake syndrome is a cyclic debilitating circadian rhythm sleep disorder characterized by an inability to sleep on a 24-hour schedule. Individuals who are physically or biologically isolated from a normal 24-hour light/dark cycle exhibit a sleep/wake cycle that is different from, and usually longer than, 24 hours. It is relatively rare in sighted patients and in some cases may be associated with delayed sleep phase disorder or psychiatric disorders. It is more common in individuals who are totally blind. This article reviews the clinical characteristics of patients who have non-24-hour sleep-wake syndrome, discusses the biologic mechanisms that may underlie its development, and describes potential treatment strategies. © 2009 Elsevier Inc. All rights reserved.

Item Type: Article
Authors :
Uchiyama, M.
Date : 2009
DOI : 10.1016/j.jsmc.2009.02.002
Uncontrolled Keywords : Blindness, Circadian rhythm sleep disorders, Free-running type, Hypernychthemeral syndrome, Melatonin, Non-24-hour sleep-wake disorder, Non-entrained type, melatonin, bedtime dosage, blindness, circadian rhythm sleep disorder, clinical feature, clinical trial, comorbidity, disease association, drug megadose, human, light dark cycle, light exposure, low drug dose, mental disease, night sleep, non 24 hour sleep wake syndrome, phototherapy, priority journal, psychosis, review, sleep time, sleep waking cycle, treatment planning
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:49
Last Modified : 17 Jun 2020 01:49

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