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Chronobiology of epilepsy: Diagnostic and therapeutic implications of chrono-epileptology

Loddenkemper, T., Lockley, S.W., Kaleyias, J. and Kothare, S.V. (2011) Chronobiology of epilepsy: Diagnostic and therapeutic implications of chrono-epileptology Journal of Clinical Neurophysiology, 28 (2). pp. 146-153.

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The combination of chronobiology and epilepsy offers novel diagnostic and therapeutic management options. Knowledge of the interactions between circadian periodicity, entrainment, sleep patterns, and epilepsy may provide additional diagnostic options beyond sleep deprivation and extended release medication formulations. It may also provide novel insights into the physiologic, biochemical, and genetic regulation processes of epilepsy and the circadian clock, rendering new treatment options. Temporal fluctuations of seizure susceptibility based on sleep homeostasis and circadian phase in selected epilepsies may provide predictability based on mathematical models. Chrono-epileptology offers opportunities for individualized patient-oriented treatment paradigms based on chrono-pharmacology, differential medication dosing, chrono-drug delivery systems, and utilization of "zeitgebers" such as chronobiotics or light-therapy and desynchronization strategies among others. Copyright © 2011 by the American Clinical Neurophysiology Society.

Item Type: Article
Authors :
Loddenkemper, T.
Kaleyias, J.
Kothare, S.V.
Date : 2011
DOI : 10.1097/WNP.0b013e31821213d4
Uncontrolled Keywords : Chronobiology, Circadian patterns, Epilepsy, Epilepsy monitoring, Seizures, 4 aminobutyric acid, adenosine, adenosine kinase inhibitor, adenosine receptor stimulating agent, anticonvulsive agent, CHRNA2 protein, corticotropin, hydrocortisone, melatonin, methylxanthine, nicotinic receptor, nicotinic receptor alpha4, nicotinic receptor beta2, serotonin, theophylline, unclassified drug, valproic acid, atonic seizure, brain depth stimulation, chronobiology, chronopharmacology, chronotherapy, circadian rhythm, cortical dysplasia, dopaminergic activity, dosage schedule comparison, drug delivery system, drug megadose, electroencephalogram, electroencephalography phase synchronization, embryotoxicity, epilepsy, epileptic discharge, epileptic state, evening dosage, gelastic seizure, genetic regulation, grand mal seizure, homeostasis, human, hydrocortisone blood level, Lennox Gastaut syndrome, mathematical model, myoclonus seizure, nocturnal seizure, nonhuman, nonREM sleep, oscillation, pathophysiology, phototherapy, prediction, REM sleep, review, seizure, seizure susceptibility, sleep deprivation, sleep pattern, sleep waking cycle, slow wave sleep, spike wave, suprachiasmatic nucleus, temporal lobe epilepsy, thalamocortical tract, tonic clonic seizure, vagus nerve stimulation, Brain, Brain Waves, Circadian Rhythm, Electroencephalography, Epilepsy, Homeostasis, Humans, Motor Activity, Neural Pathways, Predictive Value of Tests, Sleep, Sleep Disorders
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:44
Last Modified : 17 Jun 2020 01:44

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