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Randomized controlled trial of light therapy for fatigue following traumatic brain injury

Sinclair, K.L., Ponsford, J.L., Taffe, J., Lockley, S.W. and Rajaratnam, S.M.W. (2014) Randomized controlled trial of light therapy for fatigue following traumatic brain injury Neurorehabilitation and Neural Repair, 28 (4). pp. 303-313.

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Background. Fatigue is a common, persistent complaint following traumatic brain injury (TBI). Effective treatment is not well established. Objective. The current study aimed to investigate the efficacy of 4 weeks of light therapy for fatigue in patients with TBI. Methods. We undertook a randomized, placebo-controlled study of 4-week, 45 min/morning, home-based treatment with short wavelength (blue) light therapy (max = 465 nm, 84.8 μW/cm2, 39.5 lux, 1.74 � 1014 photons/cm2/s) compared with yellow light therapy (max = 574 nm, 18.5 μW/cm2, 68 lux, 1.21 � 1012 photons/cm2/s) containing less photons in the short wavelength range and a no treatment control group (n = 10 per group) in patients with TBI who self-reported fatigue and/or sleep disturbance. Assessments of fatigue and secondary outcomes (self-reported daytime sleepiness, depression, sleep quality, and sustained attention) were conducted over 10 weeks at baseline (week 2), midway through and at the end of light therapy (weeks 2 and 4), and 4 weeks following cessation of light therapy (week 8). Results. After controlling age, gender, and baseline depression, treatment with high-intensity blue light therapy resulted in reduced fatigue and daytime sleepiness during the treatment phase, with evidence of a trend toward baseline levels 4 weeks after treatment cessation. These changes were not observed with lower-intensity yellow light therapy or no treatment control conditions. There was also no significant treatment effect observed for self-reported depression or psychomotor vigilance performance. Conclusions. Blue light therapy appears to be effective in alleviating fatigue and daytime sleepiness following TBI and may offer a noninvasive, safe, and nonpharmacological alternative to current treatments. © The Author(s) 2013.

Item Type: Article
Authors :
Sinclair, K.L.
Ponsford, J.L.
Taffe, J.
Rajaratnam, S.M.W.
Date : 2014
DOI : 10.1177/1545968313508472
Uncontrolled Keywords : depression, excessive daytime sleepiness, fatigue, light therapy, sleep disturbance, traumatic brain injury, placebo, adult, age, aged, article, blue light, blue light therapy, clinical article, clinical effectiveness, controlled study, daytime somnolence, depression, fatigue, female, gender, home care, human, light emitting diode, light intensity, male, photon, phototherapy, phototherapy device, randomized controlled trial, sleep quality, traumatic brain injury, treatment duration, adolescent, brain injury, complication, fatigue, middle aged, phototherapy, regression analysis, severity of illness index, Sleep Disorders, treatment outcome, young adult, Adolescent, Adult, Brain Injuries, Fatigue, Female, Humans, Male, Middle Aged, Photons, Phototherapy, Regression Analysis, Severity of Illness Index, Sleep Disorders, Treatment Outcome, Young Adult
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:22
Last Modified : 17 Jun 2020 01:22

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