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Visual impairment and circadian rhythm sleep disorders

Lockley, S.W., Arendt, J. and Skene, D.J. (2016) Visual impairment and circadian rhythm sleep disorders In: The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., pp. 428-437. ISBN 9780128093245 (ISBN)

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Many aspects of human physiology, metabolism, and behavior are dominated by 24-h circadian rhythms including the sleep-wake cycle, alertness and performance patterns, and some hormones. These rhythms are spontaneously generated by an internal circadian clock in the brain and daily light exposure to the eyes synchronizes the clock with the external environment. Most blind people with no perception of light, however, experience continual circadian desynchrony through a failure of light information to reach the circadian pacemaker, resulting in non-24-h sleep-wake disorder. Daily melatonin administration, which provides a replacement synchronizing daily �time cue,� is a promising therapeutic strategy to treat this disorder. © 2017 Elsevier Inc. All rights reserved.

Item Type: Book Section
Authors :
Arendt, J.
Skene, D.J.
Date : 2016
DOI : 10.1016/B978-0-12-809324-5.01285-2
Uncontrolled Keywords : Advanced sleep phase disorder, Alertness, Blindness, Circadian, Delayed sleep phase disorder, Entrainment, Light, Melatonin, Non-24-h sleep-wake disorder, Performance, Sleep
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:10
Last Modified : 17 Jun 2020 01:10

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