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Melatonin regulation of circadian rhythmicity in vertebrates

Weaver, D.R. and Lockley, S.W. (2016) Melatonin regulation of circadian rhythmicity in vertebrates In: The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., pp. 721-732. ISBN 9780128093245 (ISBN)

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The pineal hormone, melatonin, influences circadian rhythms in a species-specific manner. Generally, endogenous melatonin is more important for circadian function in nonmammalian vertebrates, while in mammals the impact of melatonin is most clearly seen when exogenous melatonin is administered. The effects of melatonin on circadian rhythms in mammals are often subtle, but even small phase shifts caused by melatonin receptor activation can lead to stable entrainment. Rodent studies to identify molecular mechanisms of melatonin action emphasize the role of the MT1 receptor, but some responses appear due to the MT2 receptor subtype. © 2017 Elsevier Inc. All rights reserved.

Item Type: Book Section
Authors :
Weaver, D.R.
Date : 2016
DOI : 10.1016/B978-0-12-809324-5.02297-5
Uncontrolled Keywords : Circadian rhythms, Entrainment, Hormones, Knockout mice, Melatonin, Melatonin receptors, MT1, MT2, Phase shift, Suprachiasmatic nucleus, Tasimelteon
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:10
Last Modified : 17 Jun 2020 01:10

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