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Pineal gland volume assessed by MRI and its correlation with 6-sulfatoxymelatonin levels among older men

Sigurdardottir, L.G., Markt, S.C., Sigurdsson, S., Aspelund, T., Fall, K., Schernhammer, E., Rider, J.R., Launer, L., Harris, T., Stampfer, M.J. , Gudnason, V., Czeisler, C.A., Lockley, S.W., Valdimarsdottir, U.A. and Mucci, L.A. (2016) Pineal gland volume assessed by MRI and its correlation with 6-sulfatoxymelatonin levels among older men Journal of Biological Rhythms, 31 (5). pp. 461-469.

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The pineal gland produces the hormone melatonin, and its volume may influence melatonin levels. We describe an innovative method for estimating pineal volume in humans and present the association of pineal parenchyma volume with levels of the primary melatonin metabolite, 6-sulfatoxymelatonin. We selected a random sample of 122 older Icelandic men nested within the AGES-Reykjavik cohort and measured their total pineal volume, their parenchyma volume, and the extent of calcification and cysts. For volume estimations we used manual segmentation of magnetic resonance images in the axial plane with simultaneous side-by-side view of the sagittal and coronal plane. We used multivariable adjusted linear regression models to estimate the association of pineal parenchyma volume and baseline characteristics, including 6-sulfatoxymelatonin levels. We used logistic regression to test for differences in first morning urinary 6-sulfatoxymelatonin levels among men with or without cystic or calcified glands. The pineal glands varied in volume, shape, and composition. Cysts were present in 59% of the glands and calcifications in 21%. The mean total pineal volume measured 207 mm3 (range 65-536 mm3) and parenchyma volume 178 mm3 (range 65-503 mm3). In multivariable-adjusted models, pineal parenchyma volume was positively correlated with 6-sulfatoxymelatonin levels (β = 0.52, p < 0.001). Levels of 6-sulfatoxymelatonin did not differ significantly by presence of cysts or calcification. By using an innovative method for pineal assessment, we found pineal parenchyma volume to be positively correlated with 6-sulfatoxymelatonin levels, in line with other recent studies. © SAGE Publications.

Item Type: Article
Authors :
Sigurdardottir, L.G.
Markt, S.C.
Sigurdsson, S.
Aspelund, T.
Fall, K.
Schernhammer, E.
Rider, J.R.
Launer, L.
Harris, T.
Stampfer, M.J.
Gudnason, V.
Czeisler, C.A.
Valdimarsdottir, U.A.
Mucci, L.A.
Date : 2016
DOI : 10.1177/0748730416656948
Uncontrolled Keywords : circadian, melatonin, MRI, pineal, sleep, 6-sulfatoxymelatonin, melatonin, aged, analogs and derivatives, anatomy and histology, brain, circadian rhythm, diagnostic imaging, human, male, nuclear magnetic resonance imaging, organ size, pineal body, urine, very elderly, Aged, Aged, 80 and over, Brain, Circadian Rhythm, Humans, Magnetic Resonance Imaging, Male, Melatonin, Organ Size, Pineal Gland
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:06
Last Modified : 17 Jun 2020 01:06

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