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Scanning ion microbeam analysis of diffusion in in-mouth drug release polymers

Massingham, G., Arslanoglu, R., Gauntlett, F.E, Rihawy, M.S, Smith, Richard, Clough, A.S, Braden, M. and Patel, M. (2005) Scanning ion microbeam analysis of diffusion in in-mouth drug release polymers International Journal of PIXE, 15 (3).

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With the aim of characterizing polymer-based drug delivery systems a combination of Scanning MeV 3He microbeam Nuclear Reaction, Backscattering and Particle Induced X-ray Emission (PIXE) techniques has been developed. This, together with gravimetric and UV techniques has been applied to characterize both water infusion and drug effusion for three in-mouth polymer–drug systems. Preliminary results are presented from the exposure of polymers, containing drug at a level of 9% by weight of the dry polymer, to both pure water and a phosphate buffered saline solution at 37°C.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Massingham, G.
Arslanoglu, R.
Gauntlett, F.E
Rihawy, M.S
Clough, A.S
Braden, M.
Patel, M.
Date : 25 June 2005
DOI : 10.1142/S0129083505000477
Uncontrolled Keywords : Polymers; controlled drug delivery; water diffusion; ion beam analysis
Depositing User : James Marshall
Date Deposited : 20 Mar 2020 16:59
Last Modified : 20 Mar 2020 16:59

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