The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes
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Royston, R., Oliver, C., Howlin, P., Dosse, A., Armitage, P., Moss, J. and Waite, J. (2019) The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes Journal of Autism and Developmental Disorders.
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Abstract
Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader-Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12-57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p <.0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p =.001), generalised anxiety (p =.006) and hyperactivity (p =.003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.
| Item Type: | Article | ||||||||||||||||||||||||
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| Divisions : | Faculty of Health and Medical Sciences > School of Psychology | ||||||||||||||||||||||||
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| Date : | 4 December 2019 | ||||||||||||||||||||||||
| DOI : | 10.1007/s10803-019-04317-1 | ||||||||||||||||||||||||
| Copyright Disclaimer : | © 2019, The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ||||||||||||||||||||||||
| Uncontrolled Keywords : | Williams syndrome; Prader–Willi syndrome; Fragile X syndrome; Psychopathology; Correlates | ||||||||||||||||||||||||
| Additional Information : | This study was funded by Cerebra and the Williams Syndrome Foundation. | ||||||||||||||||||||||||
| Depositing User : | Diane Maxfield | ||||||||||||||||||||||||
| Date Deposited : | 03 Feb 2020 16:17 | ||||||||||||||||||||||||
| Last Modified : | 03 Feb 2020 16:17 | ||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/853568 |
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