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Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study

Cochran, L., Welham, A., Oliver, C., Arshad, A. and Moss, Joanna (2019) Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study Journal of Autism and Developmental Disorders, 49. pp. 2476-2487.

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Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
Cochran, L.
Welham, A.
Oliver, C.
Arshad, A.
Date : 15 June 2019
Funders : Cerebra, The Cornelia de Lange syndrome Foundation UK and Ireland
DOI : 10.1007/s10803-019-03966-6
Copyright Disclaimer : © The Author(s) 2019, corrected publication 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords : Cornelia de Lange syndrome ; Cri du Chat syndrome ; Autism spectrum disorder ; Behaviour; Age
Depositing User : Diane Maxfield
Date Deposited : 03 Mar 2020 14:59
Last Modified : 03 Mar 2020 15:00

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