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Acute kidney injury: short-term and long-term effects

Doyle, James F. and Forni, Lui G. (2016) Acute kidney injury: short-term and long-term effects Critical Care, 20 (1), 188.

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Acute kidney injury (AKI) is the most common cause of organ dysfunction in critically ill adults, with a single episode of AKI, regardless of stage, carrying a significant morbidity and mortality risk. Since the consensus on AKI nomenclature has been reached, data reflecting outcomes have become more apparent allowing investigation of both short- and long-term outcomes.

Classically the short-term effects of AKI can be thought of as those reflecting an acute deterioration in renal function per se. However, the effects of AKI, especially with regard to distant organ function (“organ cross-talk”), are being elucidated as is the increased susceptibility to other conditions. With regards to the long-term effects, the consideration that outcome is a simple binary endpoint of dialysis or not, or survival or not, is overly simplistic, with the reality being much more complex.

Also discussed are currently available treatment strategies to mitigate these adverse effects, as they have the potential to improve patient outcome and provide considerable economic health savings. Moving forward, an agreement for defining renal recovery is warranted if we are to assess and extrapolate the efficacy of novel therapies. Future research should focus on targeted therapies assessed by measure of long-term outcomes.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Doyle, James F.
Forni, Lui
Date : 3 July 2016
DOI : 10.1186/s13054-016-1353-y
Copyright Disclaimer : © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Uncontrolled Keywords : Chronic Kidney Disease; Acute Kidney Injury; Sequential Organ Failure Assessment; Continuous Renal Replacement Therapy; Kidney Disease Improve Global Outcome
Depositing User : Diane Maxfield
Date Deposited : 29 Oct 2019 10:40
Last Modified : 29 Oct 2019 10:40

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