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Population balance modelling of ribbon milling with a new mass-based breakage function

Olaleye, Busayo, Pozza, Filippo, Wu, Chuan-Yu and Liu, Lian X. (2019) Population balance modelling of ribbon milling with a new mass-based breakage function International Journal of Pharmaceutics, 118765.

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Dry granulation through roll compaction followed by milling is a widely used pharmaceutical process. The material properties of powders and the roll compaction process conditions affect the strength of ribbons, and subsequently the granule size distribution (GSD). Accurate prediction of the granule size distribution from milling of ribbons with different properties is essential for ensuring tablet quality in the final compaction stage. In this study, MCC, PH-102 ribbons with precisely controlled porosities were produced and milled in a cutting mill and granule size distribution was analysed using QicPic. A population balance model with a new breakage function based on the Weibull function was developed to model the ribbon milling process. Eight model parameters were initially obtained for each ribbon porosity and very good agreement between the model and experimental results was obtained. Sensitivity analysis was then performed and thus reduced the number of model parameters that changed with ribbon porosity to two in the breakage function. The refined model was able to predict the granule size distribution both within and outside the experimental boundaries. It was shown that the model developed in this study has a great potential for predicting granule properties and therefore the optimisation of the dry granulation process.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Pozza, Filippo
Liu, Lian
Date : 11 October 2019
DOI : 10.1016/j.ijpharm.2019.118765
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Population balance model; Ribbon milling; Breakage function; Ribbon porosity; Granule size distribution
Depositing User : Clive Harris
Date Deposited : 15 Oct 2019 12:28
Last Modified : 12 Oct 2020 02:08

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