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The pathophysiological basis and consequences of fever

Walter, E.J., Hanna-Jumma, S., Carraretto, M. and Forni, Lui (2016) The pathophysiological basis and consequences of fever Critical Care, 20 (1).

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There are numerous causes of a raised core temperature. A fever occurring in sepsis may be associated with a survival benefit. However, this is not the case for non-infective triggers. Where heat generation exceeds heat loss and the core temperature rises above that set by the hypothalamus, a combination of cellular, local, organ-specific, and systemic effects occurs and puts the individual at risk of both short-term and long-term dysfunction which, if severe or sustained, may lead to death. This narrative review is part of a series that will outline the pathophysiology of pyrogenic and non-pyrogenic fever, concentrating primarily on the pathophysiology of non-septic causes.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Walter, E.J.
Hanna-Jumma, S.
Carraretto, M.
Date : 14 July 2016
DOI : 10.1186/s13054-016-1375-5
Copyright Disclaimer : © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Uncontrolled Keywords : Hyperthermia; Fever; Organ failure; Physiopathology; Heatstroke
Depositing User : Diane Maxfield
Date Deposited : 01 Oct 2019 11:00
Last Modified : 01 Oct 2019 11:00

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