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Pragmatic studies for acute kidney injury: Consensus report of the Acute Disease Quality Initiative (ADQI) 19 Workgroup

Peng, Z., Yu, K., Ostermann, M., Xi, X., Hsu, R., Vincent, J.-L., Prowle, J.R., Du, B., Gallagher, M., Wang, C. , Murugan, R., Qiu, H., Rimmelé, T., Li, J., Forni, Lui G., Kashani, K., Ronco, C. and Kellum, J.A. (2018) Pragmatic studies for acute kidney injury: Consensus report of the Acute Disease Quality Initiative (ADQI) 19 Workgroup Journal of Critical Care, 44. pp. 337-344.

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Acute kidney injury (AKI) has become a major medical and financial burden in China along with the rest of the world. There have been considerable advances in the understanding of the epidemiology and pathogenesis of AKI. However, there is no consensus regarding the optimal care for patients. The Acute Disease Quality Initiative (ADQI) 19 meeting focused on identifying and designing relevant and achievable AKI-related studies in China.

Materials & methods:

he working group developed a list of preliminary questions and objectives and performed analysis of the existing literature. Relevant studies were identified through a literature search using the MEDLINE database and bibliographies of relevant research and review articles. We then used a two-step Delphi process to prioritize a research agenda and proposed specific study designs to address unmet needs.


Important gaps in existing knowledge were identified and pragmatic studies were proposed in three distinct areas: care bundles for AKI prevention, renal replacement therapy (RRT) for AKI, and fluid management. In addition, the use of biomarkers to guide clinical trials was discussed.


Consensus was reached on a research agenda for AKI with a specific focus on pragmatic trials in China.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Peng, Z.
Yu, K.
Ostermann, M.
Xi, X.
Hsu, R.
Vincent, J.-L.
Prowle, J.R.
Du, B.
Gallagher, M.
Wang, C.
Murugan, R.
Qiu, H.
Rimmelé, T.
Li, J.
Forni, Lui
Kashani, K.
Ronco, C.
Kellum, J.A.
Date : April 2018
DOI : 10.1016/j.jcrc.2017.12.006
Copyright Disclaimer : © 2017 Elsevier Inc. All rights reserved.
Uncontrolled Keywords : Acute kidney injury; Sepsis; Renal replacement therapy; Resuscitation; Pragmatic trials
Additional Information : This work was supported by the National Natural Science Foundation of China (ZP, 81560131) and Hubei Key Projects (ZP, WJ2017Z008).
Depositing User : Diane Maxfield
Date Deposited : 24 Oct 2019 16:13
Last Modified : 24 Oct 2019 16:13

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