Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

Kokurewicz, K., Brunetti, E., Welsh, G. H., Wiggins, S. M., Boyd, M., Sorensen, A., Chalmers, A. J., Schettino, G., Subiel, A., DesRosiers, C. et al and Jaroszynski, D. A. (2019) Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements Scientific Reports, 9, 10837. pp. 1-10.

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Abstract

The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Physics
Authors :	Name Email ORCID Kokurewicz, K. Brunetti, E. Welsh, G. H. Wiggins, S. M. Boyd, M. Sorensen, A. Chalmers, A. J. Schettino, G. giuseppe.schettino@surrey.ac.uk Subiel, A. DesRosiers, C. Jaroszynski, D. A.
Date :	25 July 2019
DOI :	10.1038/s41598-019-46630-w
Copyright Disclaimer :	© The author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Uncontrolled Keywords :	Cancer imaging; Radiotherapy
Depositing User :	Clive Harris
Date Deposited :	16 Aug 2019 07:36
Last Modified :	16 Aug 2019 07:36
URI:	http://epubs.surrey.ac.uk/id/eprint/852419

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