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Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology

Westerhoff, H.V., He, F., Murabito, E., Crémazy, F. and Barberis, Matteo (2014) Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology In: Computational Systems Biology: From Molecular Mechanisms to Disease: Second Edition. Academic Press, pp. 21-44. ISBN 978-0-12-405926-9

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Systems Biology brings the potential to discover fundamental principles of Life that cannot be discovered by considering individual molecules. This chapter discusses a number of early, more recent, and upcoming discoveries of such network principles. These range from the balancing of fluxes through metabolic networks, the potential of those networks for truly individualized medicine, the time dependent control of fluxes and concentrations in metabolism and signal transduction, the ways in which organisms appear to regulate metabolic processes vis-à-vis limitations therein, tradeoffs in robustness and fragility, and a relation between robustness and time dependences in the cell cycle. The robustness considerations will lead to the issue whether and how evolution has been able to put in place design principles of control engineering such as infinite robustness and perfect adaptation in the hierarchical biochemical networks of cell biology © 2014 Elsevier Inc. All rights reserved.

Item Type: Book Section
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Westerhoff, H.V.
He, F.
Murabito, E.
Crémazy, F.
Date : 2014
Funders : Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), European Commission 7th Framework Programme
DOI : 10.1016/B978-0-12-405926-9.00003-4
Grant Title : Manchester Centre for Integrative Systems Biology
Uncontrolled Keywords : Cell cycle; Flux Balance Analysis (FBA); Flux control coefficients; Fragility; Metabolic network; Objective-based modelling; Perfect adaptation; Robustness; Topology
Additional Information : This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modelling.
Depositing User : Clive Harris
Date Deposited : 15 Apr 2019 13:23
Last Modified : 15 Apr 2019 13:23

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