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In vitro and sensory tests to design easy-to-swallow multi-particulate formulations

Marconati, Marco, Lopez, Felipe, Tuleu, Catherine, Orlu, Mine and Ramaioli, Marco (2019) In vitro and sensory tests to design easy-to-swallow multi-particulate formulations European Journal of Pharmaceutical Sciences, 132. pp. 157-162.

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Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and tablets. This study proposes the use of an in vitro model to quantitatively investigate the swallowing dynamics in presence of multiparticulates. In vitro results were compared against sensory tests that considered the attributes of ease of swallowing and post-swallow residues. Water and hydrocolloids were considered as suspending vehicles, while the suspended phase consisted of cellulose pellets of two different average sizes. Both in vivo and in vitro tests reported easier swallow for smaller multi-particulates. Besides, water thin liquids appeared not optimal for complete oral clearance of the solids. The sensory study did not highlight significant differences between the levels of thickness of the hydrocolloids. Conversely, more discriminant results were obtained from in vitro tests, suggesting that a minimum critical viscosity is necessary to enable a smooth swallow, but increasing too much the carrier concentration affects swallowing negatively. These results highlight the important interplay of particle size and suspending vehicle rheology and the meaningful contribution that in vitro methods can provide to pre-screening multi-particulate oral drug delivery systems before sensory evaluation.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Lopez, Felipe
Tuleu, Catherine
Orlu, Mine
Date : 30 April 2019
DOI : 10.1016/j.ejps.2019.02.026
Copyright Disclaimer : © 2019 Elsevier B.V. All rights reserved.
Uncontrolled Keywords : Swallowing, Solid oral dosage forms, Multi-particulate, Flexible dosing, Vehicle rheology
Depositing User : Users 6648 not found.
Date Deposited : 05 Apr 2019 15:27
Last Modified : 15 Mar 2020 02:08

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