Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil

Creagh-Brown, B C, Nicholson, A.G., Showkathali, R., Gibbs, J.S.R. and Howard, L.S.G.E. (2008) Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil Thorax, 63 (10). pp. 933-934.

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Abstract

Pulmonary veno-occlusive disease (PVOD) is a disorder which causes progressive pulmonary hypertension, usually presenting with worsening dyspnoea and right heart failure. Pulmonary oedema induced by pulmonary vasodilator therapy to reduce pulmonary arterial pressure has been well described in PVOD, but here we describe a case of PVOD presenting with recurrent episodes of acute non-cardiogenic pulmonary oedema, in the absence of significant pulmonary hypertension. Concern over the risk of precipitating pulmonary oedema led us to use inhaled nitric oxide to predict the safety and efficacy of sildenafil.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :	Name Email ORCID Creagh-Brown, B C b.creagh-brown@surrey.ac.uk Nicholson, A.G. Showkathali, R. Gibbs, J.S.R. Howard, L.S.G.E.
Date :	26 September 2008
DOI :	10.1136/thx.2007.088831
Depositing User :	Clive Harris
Date Deposited :	26 Mar 2019 11:38
Last Modified :	26 Mar 2019 11:38
URI:	http://epubs.surrey.ac.uk/id/eprint/850780

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