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SRAGE: A useful biomarker in acute lung injury?

Creagh-Brown, Benedict C., Burke-Gaffney, Anne and Evans, Timothy W. (2011) SRAGE: A useful biomarker in acute lung injury? Critical Care Medicine, 39 (3). pp. 589-590.

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Numerous studies of putative biomarkers in patients with acute lung injury (ALI) have been conducted to date, but none has proved worthy of entering routine clinical practice, largely because they have shown no clear advantage over clinical predictors (1, 2). Furthermore, the exemplar biomarker for ALI would be biologically plausible, sensitive, and highly specific, adding prognostic information independent of existing systems. The marker should also vary in proportion to the severity of injury and reflect the effects of therapeutic intervention. Conceivably, it would identify subgroups of patients who would benefit from specific therapies targeted at relevant pathogenetic pathways. Ideally, it would be inexpensive and rapidly quantified in a highly reproducible fashion. In this context, a prospective study published in this issue of Critical Care Medicine by Jabaudon et al (3) investigates whether the soluble form of the receptor for advanced glycation end products (sRAGE), is a valuable biomarker in patients with ALI regardless of whether it was associated with severe sepsis or septic shock.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Creagh-Brown, Benedict
Burke-Gaffney, Anne
Evans, Timothy W.
Date : 1 March 2011
DOI : 10.1097/CCM.0b013e31820a8350
Depositing User : Clive Harris
Date Deposited : 20 Mar 2019 11:52
Last Modified : 20 Mar 2019 12:08

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