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The threshold detectable mass diameter for 2D-mammography and digital breast tomosynthesis

Hadjipanteli, Andria, Elangovan, Premkumar, Mackenzie, Alistair, Wells, Kevin, Dance, David R. and Young, Kenneth C. (2019) The threshold detectable mass diameter for 2D-mammography and digital breast tomosynthesis PHYSICA MEDICA, 57. pp. 25-32.

K-Wells-The_threshold_detectable_mass-main.pdf - Accepted version Manuscript

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Digital breast tomosynthesis (DBT) is currently under consideration for replacement of, or combined use with 2D-mammography in national breast screening programmes. To investigate the potential benefits that DBT can bring to screening, the threshold detectable lesion diameters were measured for different forms of DBT in comparison to 2D-mammography. The aim of this study was to compare the threshold detectable mass diameters obtained with narrow angle (15°/15 projections) and wide angle (50°/25 projections) DBT in comparison to 2Dmammography. Simulated images of 60mm thick compressed breasts were produced with and without masses using a set of validated image modelling tools for 2D-mammography and DBT. Image processing and reconstruction were performed using commercial software. A series of 4-alternative forced choice (4AFC) experiments was conducted for signal detection with the masses as targets. The threshold detectable mass diameter was found for each imaging modality with a mean glandular dose of 2.5 mGy. The resulting values of the threshold diameter for 2D-mammography (10.2 ± 1.4 mm) were found to be larger (p < 0.001) than those for narrow angle DBT (6.0 ± 1.1 mm) and wide angle DBT (5.6 ± 1.2 mm). There was no significant difference between the threshold diameters for wide and narrow angle DBT. Implications for the introduction of DBT alone or in combination with 2D-mammography in breast cancer screening are discussed.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Hadjipanteli, Andria
Elangovan, Premkumar
Mackenzie, Alistair
Dance, David R.
Young, Kenneth C.
Date : January 2019
Funders : Cancer Research UK
DOI : 10.1016/j.ejmp.2018.11.014
Copyright Disclaimer : © 2018 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.
Uncontrolled Keywords : 2D-mammography; Digital breast tomosynthesis; Masses
Depositing User : Diane Maxfield
Date Deposited : 07 Feb 2019 12:02
Last Modified : 18 Dec 2019 02:08

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