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PRaVDA: The first solid-state system for proton computed tomography

Esposito, Michela, Waltham, Chris, Taylor, Jonathan T., Manger, Sam, Phoenix, Ben, Price, Tony, Poludniowski, Gavin, Green, Stuart, Evans, Philip M, Allport, Philip P. , Manolopulos, Spyros, Nieto-Camero, Jaime, Symons, Julyan and Allinson, Nigel M. (2018) PRaVDA: The first solid-state system for proton computed tomography Physica Medica, 55. pp. 149-154.

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Purpose Proton CT is widely recognised as a beneficial alternative to conventional X-ray CT for treatment planning in proton beam radiotherapy. A novel proton CT imaging system, based entirely on solid-state detector technology, is presented. Compared to conventional scintillator-based calorimeters, positional sensitive detectors allow for multiple protons to be tracked per read out cycle, leading to a potential reduction in proton CT scan time. Design and characterisation of its components are discussed. An early proton CT image obtained with a fully solid-state imaging system is shown and accuracy (as defined in Section IV) in Relative Stopping Power to water (RSP) quantified.

Method A solid-state imaging system for proton CT, based on silicon strip detectors, has been developed by the PRaVDA collaboration. The system comprises a tracking system that infers individual proton trajectories through an imaging phantom, and a Range Telescope (RT) which records the corresponding residual energy (range) for each proton. A back-projection-then-filtering algorithm is used for CT reconstruction of an experimentally acquired proton CT scan.

Results An initial experimental result for proton CT imaging with a fully solid-state system is shown for an imaging phantom, namely a 75 mm diameter PMMA sphere containing tissue substitute inserts, imaged with a passively-scattered 125 MeV beam. Accuracy in RSP is measured to be 1.6% for all the inserts shown.

Conclusions A fully solid-state imaging system for proton CT has been shown capable of imaging a phantom with protons and successfully improving RSP accuracy. These promising results, together with system the capability to cope with high proton fluences (2x108 protons/s), suggests that this research platform could improve current standards in treatment planning for proton beam radiotherapy.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Esposito, Michela
Waltham, Chris
Taylor, Jonathan T.
Manger, Sam
Phoenix, Ben
Price, Tony
Poludniowski, Gavin
Green, Stuart
Evans, Philip
Allport, Philip P.
Manolopulos, Spyros
Nieto-Camero, Jaime
Symons, Julyan
Allinson, Nigel M.
Date : November 2018
Funders : Wellcome Trust
DOI : 10.1016/j.ejmp.2018.10.020
Copyright Disclaimer : © 2018 The Authors. Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica. This is an open access article under the CC BY license (
Uncontrolled Keywords : Proton therapy, proton CT Elsevier, solid state detectors
Depositing User : Melanie Hughes
Date Deposited : 13 Nov 2018 12:26
Last Modified : 10 Jun 2019 14:50

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