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Area Specificity and Topography of Thalamocortical Projections Are Controlled by ephrin/Eph Genes

Dufour, Audrey, Seibt, Julie, Passante, Lara, Depaepe, Vanessa, Ciossek, Thomas, Frisén, Jonas, Kullander, Klas, Flanagan, John G, Polleux, Franck and Vanderhaeghen, Pierre (2003) Area Specificity and Topography of Thalamocortical Projections Are Controlled by ephrin/Eph Genes Neuron, 39 (3). pp. 453-465.

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The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamocortical (TC) axons. In addition, we show that the same ephrin/Eph genes unexpectedly control the inter-areal specificity of TC projections through the early topographic sorting of TC axons in an intermediate target, the ventral telencephalon. Our results constitute the first identification of guidance cues involved in inter-areal specificity of TC projections and demonstrate that the same set of mapping labels is used differentially for the generation of topographic specificity of TC projections between and within individual cortical areas.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Dufour, Audrey
Passante, Lara
Depaepe, Vanessa
Ciossek, Thomas
Frisén, Jonas
Kullander, Klas
Flanagan, John G
Polleux, Franck
Vanderhaeghen, Pierre
Date : 2 August 2003
DOI : 10.1016/S0896-6273(03)00440-9
Depositing User : Melanie Hughes
Date Deposited : 28 Aug 2018 13:45
Last Modified : 28 Aug 2018 13:45

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