Impaired Red Blood Cell Deformability in Patients with Coronary Artery Disease and Diabetes Mellitus

Keymel, S., Heiss, C., Kleinbongard, P., Kelm, M. and Lauer, T. (2011) Impaired Red Blood Cell Deformability in Patients with Coronary Artery Disease and Diabetes Mellitus HORMONE AND METABOLIC RESEARCH, 43 (11). pp. 760-765.

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Abstract

Patients with diabetes mellitus (DM) have an increased cardiovascular morbidity and mortality. There is increasing evidence that diabetes mellitus is associated with pathological hemorheological alterations, which might contribute to impaired coronary blood flow in coronary artery disease (CAD). We hypothesize that red blood cell (RBC) deformability is impaired in diabetic patients with CAD in comparison to nondiabetic patients with CAD. RBC deformability was measured in 21 patients with CAD and type 2 diabetes mellitus (CAD+DM) and 24 patients with CAD (CAD–DM). RBC deformability was measured by the Laser-assisted optical rotational cell analyzer by determining the elongation index (EI). RBC deformability was reduced in patients with CAD+DM in comparison to patients with CAD–DM (EI @ 1.12 Pa 0.236 ± 0.008 vs. 0.260 ± 0.005, p = 0.007). Inverse univariate correlations were found between the EI @ 1.12 Pa and plasma glucose concentration (r =-0.57; p<0.001) and HbA1c (r =-0.45; p = 0.002). Multivariate linear regression analysis identified plasma glucose concentration as the independent predictor of RBC deformability (β=-0.58; p = 0.007) thereby indicating that increased glucose concentrations determine RBC deformability in diabetic patients with CAD. In patients with CAD, diabetes mellitus leads to an impairment of RBC deformability which might contribute to increased morbidity of diabetic patients with CAD.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine Faculty of Health and Medical Sciences > School of Biosciences and Medicine Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Keymel, S. Heiss, C. c.heiss@surrey.ac.uk Kleinbongard, P. Kelm, M. Lauer, T.
Date :	2011
DOI :	10.1055/s-0031-1286325
Copyright Disclaimer :	© Georg Thieme Verlag KG Stuttgart · New York
Uncontrolled Keywords :	Hemorheology; Diabetic complications; Atherosclerosis
Depositing User :	Diane Maxfield
Date Deposited :	16 Aug 2018 11:21
Last Modified :	16 Aug 2018 11:21
URI:	http://epubs.surrey.ac.uk/id/eprint/848974

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