Cardiovascular remodeling after AVF surgery in rats assessed by a clinical MRI scanner
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Langer, Stephan, Paulus, Niklas, Heiss, Christian, Koeppel, Thomas A., Greiner, Andreas, Buhl, Alexandra, Lauer, Thomas, Kokozidou, Maria, Jacobs, Michael J. and Krombach, Gabriele A. (2011) Cardiovascular remodeling after AVF surgery in rats assessed by a clinical MRI scanner MAGNETIC RESONANCE IMAGING, 29 (1). pp. 57-63.
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Official URL: https://doi.org/10.1016/j.mri.2010.07.010
Abstract
Purpose
To evaluate a cardiovascular magnetic resonance imaging (MRI) technique which allows the longitudinal analysis of cardiovascular remodeling in a rodent femoral arteriovenous fistula (AVF) model by means of a clinical scanner.
Materials and Methods
Eight rats underwent femoral AVF surgery and four rats served as controls. Vascular and cardiac morphology as well as cardiac function was assessed from Week 3 to 12 using contrast-enhanced, time-resolved magnetic resonance angiography (MRA) and cardiac MRI (cine gradient-echo sequence) at 3 T in one imaging session.
Results
Arteriovenous surgery resulted in progressive venous dilation and a subsequent cardiac adaptation. This procedure led to downstream vasodilation of the iliac vein and inferior vena cava of 179% and 188%, respectively (3 weeks). To accommodate the increased returning blood volume, cardiac output (CO) increased significantly (P=.014; 6 weeks). This was caused by increased end-diastolic volume (EDV), stroke volume (SV) and heart rate (HR) consistent with an increased volume load. A continuous increase in heart weight peaked at 12 weeks. This increase combined with a distinct end-diastolic left ventricular dilation implied eccentric hypertrophy.
Conclusion
Small rodent MRI is feasible and clearly depicts fistula maturation and cardiac alterations. This technique proved to be a valuable tool for longitudinal in vivo monitoring in this model, which strongly resembles clinical findings in hemodialysis patients.
| Item Type: | Article | |||||||||||||||||||||||||||||||||
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| Divisions : |
Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine Faculty of Health and Medical Sciences > School of Biosciences and Medicine Faculty of Health and Medical Sciences |
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| Date : | January 2011 | |||||||||||||||||||||||||||||||||
| DOI : | 10.1016/j.mri.2010.07.010 | |||||||||||||||||||||||||||||||||
| Copyright Disclaimer : | Copyright © 2011 Elsevier Inc. All rights reserved. | |||||||||||||||||||||||||||||||||
| Uncontrolled Keywords : | Arteriovenous fistula; Animal model; Cardiovascular MRI | |||||||||||||||||||||||||||||||||
| Depositing User : | Diane Maxfield | |||||||||||||||||||||||||||||||||
| Date Deposited : | 15 Aug 2018 15:20 | |||||||||||||||||||||||||||||||||
| Last Modified : | 15 Aug 2018 15:20 | |||||||||||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/848956 |
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