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Platelet 5-hydroxytryptamine uptake in affective disorders.

Swade, Cynthia C. (1983) Platelet 5-hydroxytryptamine uptake in affective disorders. Doctoral thesis, University of Surrey (United Kingdom)..

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There is evidence that blood platelets accumulate, store and release 5-hydroxytryptamine (5-HT, serotonin) in a manner analagous to the central nervous system serotonergic synaptosome. The biogenic amine hypothsis of affective disorders states that depression is associated with a deficiency of brain 5-HT. Therefore, a study was carried out to compare the platelet 5-HT uptake characteristics of platelets from depressive patients and healthy control subjects. The rate of platelet 5-HT uptake was lower in depressive patients than in age and sex matched control subjects. There was no correlation between severity of illness and rate of 5-HT uptake, and the results for a group of patients tested both when depressed and again after recovery were similar on the two occasions. It is suggested that a low rate of 5-HT uptake is a trait contributing to a predisposition to depressive illness. A seasonal variation in 5-HT transport was observed in both controls and patients. The rate of 5-HT uptake was lowest in late spring and early summer, which is also the time of year of greatest incidence of depression and the peak in the suicide rate. Inhibition of 5-HT uptake was observed in depressed patients treated with either amitriptyline or zimelidine. The extent of inhibition of 5-HT transport was related to plasma drug concentrations, but did not correlate with clinical improvement. Prophylactic treatment with lithium increased the rate of platelet 5-HT uptake towards normal values in both unipolar and bipolar patients. The significance of these findings and their possible relationship to some other biochemical abnormalities observed in depressive patiente are discussed.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
Swade, Cynthia C.
Date : 1983
Contributors :
Additional Information : Thesis (Ph.D.)--University of Surrey (United Kingdom), 1983.
Depositing User : EPrints Services
Date Deposited : 22 Jun 2018 14:26
Last Modified : 06 Nov 2018 16:53

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