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Unconventional RNA-binding proteins: an uncharted zone in RNA biology

Albihlal, Waleed S and Gerber, André P (2018) Unconventional RNA-binding proteins: an uncharted zone in RNA biology FEBS Letters, 592 (17). pp. 2917-2931.

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RNA-binding proteins play essential roles in the post-transcriptional regulation of gene expression. While hundreds of RNA-binding proteins can be predicted computationally, the recent introduction of proteome-wide approaches has dramatically expanded the repertoire of proteins interacting with RNA. Besides canonical RNA-binding proteins that contain characteristic RNA-binding domains, many proteins that lack such domains but have other well-characterised cellular functions were identified; including metabolic enzymes, heat shock proteins, kinases, as well as transcription factors and chromatin-associated proteins. In the context of these recently published RNA-protein interactome datasets obtained from yeast, nematodes, flies, plants and mammalian cells, we discuss examples for seemingly evolutionary conserved “unconventional” RNA-binding proteins that act in central carbon metabolism, stress response or regulation of transcription.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Albihlal, Waleed
Gerber, André
Date : 16 June 2018
Funders : Biotechnology and Biological Sciences Research Council (BBSRC)
DOI : 10.1002/1873-3468.13161
Copyright Disclaimer : © 2018 Federation of European Biochemical Societies
Uncontrolled Keywords : RNA-binding protein; Post-transcriptional gene regulation; Metabolism; Heat shock; Transcription
Depositing User : Clive Harris
Date Deposited : 19 Jun 2018 11:06
Last Modified : 17 Jun 2019 02:08

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