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Coherent aperture-synthesis, wide-field, high-resolution holographic microscopy of biological tissue

Gutzler, T., Hillman, T.R., Alexandrov, S.A. and Sampson, D.D. (2010) Coherent aperture-synthesis, wide-field, high-resolution holographic microscopy of biological tissue Optics Letters, 35 (8). pp. 1136-1138.

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We show for the first time, to our knowledge, high-resolution wide-field images of biological samples recorded using coherent aperture-synthesis Fourier holography. To achieve this, we combined off-axis plane-wave polarized illumination with an axial sample rotation and polarization-sensitive collection of backscat- tered light. We synthesized 180 Fourier holograms using an efficient postdetection phase-matching correlation scheme. The result was an annular spatial frequency-space synthetic aperture (NA=0.93) with an effective area 25 times larger than that due to a single hologram. A high-resolution high-contrast microscopic reconstruction of biological tissue was computed over a sample area of 9mm2 from holograms acquired at 34 mm working distance.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Gutzler, T.
Hillman, T.R.
Alexandrov, S.A.
Date : 2010
DOI : 10.1364/OL.35.001136
Uncontrolled Keywords : Holography, Phase matching, Synthetic apertures, Tissue, Aperture synthesis, Biological samples, Biological tissues, Fourier holograms, Fourier holography, Holographic microscopy, Polarization sensitive, Polarized illumination, Holograms, article, cytology, holography, human, image processing, lymph node, methodology, microscopy, pathology, Holography, Humans, Image Processing, Computer-Assisted, Lymph Nodes, Microscopy
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:11
Last Modified : 19 Sep 2018 11:32

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