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Ultrathin side-viewing needle probe for optical coherence tomography

Lorenser, D., Yang, X., Kirk, R.W., Quirk, B.C., McLaughlin, R.A. and Sampson, D.D. (2011) Ultrathin side-viewing needle probe for optical coherence tomography Optics Letters, 36 (19). pp. 3894-3896.

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We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an anglepolished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe's inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840nm spectral-domain OCT system and the measured sensitivity was shown to be only 7 dB lower than that of a comparable galvo-scanning sample arm configuration. 3D OCT images of lamb lungs were acquired over a depth range of ∼600 μm, showing individual alveoli and bronchioles.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Lorenser, D.
Yang, X.
Kirk, R.W.
Quirk, B.C.
McLaughlin, R.A.
Date : 2011
DOI : 10.1364/OL.36.003894
Uncontrolled Keywords : All fiber, Beam deflectors, Beam diameters, Biological tissues, Depth of field, Depth range, Interstitial fluids, Needle probes, Optical characterization, Outer diameters, Probe design, Spectral-domain, Ultra-thin, Working distances, Needles, Optical tomography, Three dimensional, Tissue, Probes, glass fiber, animal, article, cattle, cytology, electronics, endoscope, endoscopy, equipment design, female, fiber optics, instrumentation, lung, methodology, optical coherence tomography, pregnancy, sensitivity and specificity, three dimensional imaging, Animals, Cattle, Endoscopes, Endoscopy, Equipment Design, Female, Fiber Optic Technology, Imaging, Three-Dimensional, Lung, Miniaturization, Optical Fibers, Pregnancy, Sensitivity and Specificity, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 16:04
Last Modified : 19 Sep 2018 11:32

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