Optofluidic needle probe integrating targeted delivery of fluid with optical coherence tomography imaging

Quirk, B.C., McLaughlin, R.A., Pagnozzi, A.M., Kennedy, B.F., Noble, P.B. and Sampson, David (2014) Optofluidic needle probe integrating targeted delivery of fluid with optical coherence tomography imaging Optics Letters, 39 (10). pp. 2888-2891.

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Abstract

We present an optofluidic optical coherence tomography (OCT) needle probe capable of modifying the local optical properties of tissue to improve needle-probe imaging performance. The side-viewing probe comprises an all-fiberoptic design encased in a hypodermic needle (outer diameter 720 μm) and integrates a coaxial fluid-filled channel, terminated by an outlet adjacent to the imaging window, allowing focal injection of fluid to a target tissue. This is the first fully integrated OCT needle probe design to incorporate fluid injection into the imaging mechanism. The utility of this probe is demonstrated in air-filled sheep lungs, where injection of small quantities of saline is shown, by local refractive index matching, to greatly improve image penetration through multiple layers of alveoli. 3D OCT images are correlated against histology, showing improvement in the capability to image lung structures such as bronchioles and blood vessels.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Quirk, B.C. McLaughlin, R.A. Pagnozzi, A.M. Kennedy, B.F. Noble, P.B. Sampson, David d.sampson@surrey.ac.uk
Date :	2014
DOI :	10.1364/OL.39.002888
Uncontrolled Keywords :	Blood vessels, Needles, Probes, Refractive index, Tissue, Fluid injections, Fully integrated, Hypodermic needles, Imaging mechanism, Imaging performance, Outer diameters, Refractive index matching, Targeted delivery, Optical tomography, contrast medium, sodium chloride, animal, cytology, device failure analysis, devices, diagnostic use, equipment design, in vitro study, lung, microelectromechanical system, microfluidics, needle, optical coherence tomography, optical instrumentation, sheep, signal processing, system analysis, Animals, Contrast Media, Equipment Design, Equipment Failure Analysis, In Vitro Techniques, Lung, Micro-Electrical-Mechanical Systems, Microfluidics, Needles, Optical Devices, Sheep, Signal Processing, Computer-Assisted, Sodium Chloride, Systems Integration, Tomography, Optical Coherence
Depositing User :	Maria Rodriguez-Marquez
Date Deposited :	05 Jun 2018 09:22
Last Modified :	19 Sep 2018 11:32
URI:	http://epubs.surrey.ac.uk/id/eprint/846795

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