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Three-dimensional optical coherence microelastography of skeletal muscle tissue

Chin, L., Kennedy, B.F., Kennedy, K.M., Wijesinghe, P., Pinniger, G.J., Terrill, J.R., McLaughlin, R.A. and Sampson, David (2014) Three-dimensional optical coherence microelastography of skeletal muscle tissue Biomedical Optics Express, 5 (9). pp. 3090-3102.

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In many muscle pathologies, impairment of skeletal muscle function is closely linked to changes in the mechanical properties of the muscle constituents. Optical coherence micro-elastography (OCME) uses optical coherence tomography (OCT) imaging of tissue under a quasi-static, compressive mechanical load to map variations in tissue mechanical properties on the micro-scale. We present the first study of OCME on skeletal muscle tissue. We show that this technique can resolve features of muscle tissue including fibers, fascicles and tendon, and can also detect necrotic lesions in skeletal muscle from the mdx mouse model of Duchenne muscular dystrophy. In many instances, OCME provides better or additional contrast complementary to that provided by OCT. These results suggest that OCME could provide new understanding and opportunity for assessment of skeletal muscle pathologies.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Chin, L.
Kennedy, B.F.
Kennedy, K.M.
Wijesinghe, P.
Pinniger, G.J.
Terrill, J.R.
McLaughlin, R.A.
Date : 2014
DOI : 10.1364/BOE.5.003090
Uncontrolled Keywords : Biomechanics, Mechanical properties, Medical imaging, Muscle, Musculoskeletal system, Optical tomography, Pathology, Duchenne muscular dystrophies, Elastography, Mechanical loads, Mouse models, Muscle tissues, Quasi-static, Skeletal muscle, Tissue, animal model, disease model, elastography, model, muscle tissue, optical coherence tomography, skeletal muscle, tendon, X chromosome linked muscular dystrophic mouse
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:49
Last Modified : 19 Sep 2018 11:32

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