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Analysis of image formation in optical coherence elastography using a multiphysics approach

Chin, L., Curatolo, A., Kennedy, B.F., Doyle, B.J., Munro, P.R.T., McLaughlin, R.A. and Sampson, David (2014) Analysis of image formation in optical coherence elastography using a multiphysics approach Biomedical Optics Express, 5 (9). pp. 2913-2930.

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Image formation in optical coherence elastography (OCE) results from a combination of two processes: the mechanical deformation imparted to the sample and the detection of the resulting displacement using optical coherence tomography (OCT). We present a multiphysics model of these processes, validated by simulating strain elastograms acquired using phase- sensitive compression OCE, and demonstrating close correspondence with experimental results. Using the model, we present evidence that the approximation commonly used to infer sample displacement in phase-sensitive OCE is invalidated for smaller deformations than has been previously considered, significantly affecting the measurement precision, as quantified by the displacement sensitivity and the elastogram signal-to-noise ratio. We show how the precision of OCE is affected not only by OCT shot-noise, as is usually considered, but additionally by phase decorrelation due to the sample deformation. This multiphysics model provides a general framework that could be used to compare and contrast different OCE techniques.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Chin, L.
Curatolo, A.
Kennedy, B.F.
Doyle, B.J.
Munro, P.R.T.
McLaughlin, R.A.
Date : 2014
DOI : 10.1364/BOE.5.002913
Uncontrolled Keywords : Deformation, De correlations, Measurement precision, Mechanical deformation, Multi-physics, Multi-physics modeling, Optical coherence elastography, Phase-sensitive, Sample deformation, Optical tomography
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:47
Last Modified : 19 Sep 2018 11:32

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