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Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking

Gong, P., Chin, L., Es'Haghian, S., Liew, Y.M., Wood, F.M., Sampson, David and McLaughlin, R.A. (2014) Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking Journal of Biomedical Optics, 19 (12).

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We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2 ± 0.2 (mean ± standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1 ± 0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Gong, P.
Chin, L.
Es'Haghian, S.
Liew, Y.M.
Wood, F.M.
McLaughlin, R.A.
Date : 2014
DOI : 10.1117/1.JBO.19.12.126014
Uncontrolled Keywords : birefringence, burn scars, collagen, hypertrophic scars, normotrophic scars, parametric imaging, polarization-sensitive optical coherence tomography, speckle decorrelation, vascular masking, vessel detection, Birefringence, Blood vessels, Capillary flow, Collagen, Polarization, Tomography, Burn scar, Hypertrophic scar, normotrophic scars, Parametric imaging, Polarization sensitive optical coherence tomography, Speckle decorrelation, Vessel detection, Optical tomography, adult, birefringence, chemistry, devices, equipment design, female, human, image processing, male, middle aged, optical coherence tomography, pathology, procedures, scar, skin, vascularization, Adult, Birefringence, Cicatrix, Equipment Design, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Skin, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:53
Last Modified : 19 Sep 2018 11:32

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