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Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation

Gong, P., Es'haghian, S., Harms, K.-A., Murray, A., Rea, S., Kennedy, B.F., Wood, F.M., Sampson, David and Mclaughlin, R.A. (2016) Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation Journal of Biophotonics, 9 (6). pp. 626-636.

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This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment period. Through reliable co‐location of the imaging field of view across multiple imaging sessions, and compensation for motion artifact, the study was able to track the same scar tissue over a period of several months, and quantify changes in the vasculature area density. The results show incidences of occlusion of individual vessels 3 days after the first treatment. The subsequent responses ˜20 weeks after the initial treatment show differences between immature and mature scars. Image analysis showed a distinct decrease (25 ± 13%, mean ± standard deviation) and increase (19 ± 5%) of vasculature area density for the immature and mature scars, respectively. This study establishes the feasibility of OCT imaging for quantitative longitudinal monitoring of vasculature in scar treatment.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Gong, P.
Es'haghian, S.
Harms, K.-A.
Murray, A.
Rea, S.
Kennedy, B.F.
Wood, F.M.
Mclaughlin, R.A.
Date : 2016
DOI : 10.1002/jbio.201500157
Uncontrolled Keywords : Ablative fractional laser treatment, Angiogenesis, Burn scars, Immature scars, Mature scars, Optical coherence tomography, Speckle decorrelation, Vasculature, Climate change, Speckle, Tomography, Angiogenesis, Burn scar, Immature scars, Laser treatment, Mature scars, Speckle decorrelation, Vasculature, Optical tomography, adult, Burns, Cicatrix, diagnostic imaging, female, human, laser, male, microvasculature, middle aged, optical coherence tomography, young adult, Adult, Burns, Cicatrix, Female, Humans, Lasers, Male, Microvessels, Middle Aged, Tomography, Optical Coherence, Young Adult
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 09:28
Last Modified : 19 Sep 2018 11:32

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