Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

Gong, P., Es'haghian, S., Harms, K.-A., Murray, A., Rea, S., Wood, F.M., Sampson, David and McLaughlin, R.A. (2017) Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

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Abstract

We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ~30-150 μm) separate from the blood microvasculature network.

Item Type:	Conference or Workshop Item (UNSPECIFIED)
Divisions :	Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Gong, P. Es'haghian, S. Harms, K.-A. Murray, A. Rea, S. Wood, F.M. Sampson, David d.sampson@surrey.ac.uk McLaughlin, R.A.
Date :	2017
DOI :	10.1109/IPCon.2016.7831014
Uncontrolled Keywords :	attenuation coefficient, blood vessel, burn scars, lymphatic vessel, Optical coherence tomography (OCT), speckle decorrelation, Blood vessels, Patient treatment, Photonics, Sensitivity analysis, Tomography, Attenuation coefficient, Burn scar, Light attenuation, Lymphatic vessels, Micro-vasculature, Pilot demonstrations, Speckle decorrelation, Systematic variation, Optical tomography
Depositing User :	Maria Rodriguez-Marquez
Date Deposited :	04 Jun 2018 08:11
Last Modified :	19 Sep 2018 11:32
URI:	http://epubs.surrey.ac.uk/id/eprint/846744

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