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In vivo volumetric quantitative microelastography of human skin

Es’haghian, S., Kennedy, K.M., Gong, P., Li, Q., Chin, L., Wijesinghe, P., Sampson, David, McLaughlin, R.A. and Kennedy, B.F. (2017) In vivo volumetric quantitative microelastography of human skin Biomedical Optics Express, 8 (5). pp. 2458-2471.

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In this paper, we demonstrate in vivo volumetric quantitative micro-elastography of human skin. Elasticity is estimated at each point in the captured volume by combining local axial strain measured in the skin with local axial stress estimated at the skin surface. This is achieved by utilizing phase-sensitive detection to measure axial displacements resulting from compressive loading of the skin and an overlying, compliant, transparent layer with known stress/strain behavior. We use an imaging probe head that provides optical coherence tomography imaging and compression from the same direction. We demonstrate our technique on a tissue phantom containing a rigid inclusion, and present in vivo elastograms acquired from locations on the hand, wrist, forearm and leg of human volunteers.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Es’haghian, S.
Kennedy, K.M.
Gong, P.
Li, Q.
Chin, L.
Wijesinghe, P.
McLaughlin, R.A.
Kennedy, B.F.
Date : 2017
DOI : 10.1364/BOE.8.002458
Uncontrolled Keywords : Medical imaging, Optical tomography, Stress analysis, Axial displacements, Compressive loading, Human volunteers, Imaging probe, Phase sensitive detection, Rigid inclusion, Tissue phantom, Transparent layers, Skin, adult, Article, burn scar, case report, compression, elasticity, elastography, female, human, leg, male, nevus, optical coherence tomography, phantom, photography, quantitative analysis, skin, skin surface
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 07:51
Last Modified : 19 Sep 2018 11:32

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