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Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine

Holzer, B, Morgan, S, Matsuoka, Y, Edmans, M, Salguero Bodes, Francisco, Everett, H, Brookes, S, Porter, E, MacLoughlin, R, Charleston, B , Subbarao, K, Townsend, A and Tchilian, E (2018) Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine Journal of Immunology, 200 (12). pp. 4068-4077.

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Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Holzer, B
Morgan, S
Matsuoka, Y
Edmans, M
Salguero Bodes,
Everett, H
Brookes, S
Porter, E
MacLoughlin, R
Charleston, B
Subbarao, K
Townsend, A
Tchilian, E
Date : 27 April 2018
Funders : BBSRC
DOI : 10.4049/jimmunol.1800142
Copyright Disclaimer : Copyright 2018 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.
Depositing User : Melanie Hughes
Date Deposited : 11 Apr 2018 11:04
Last Modified : 11 Dec 2018 11:24

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