Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine
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Holzer, B, Morgan, S, Matsuoka, Y, Edmans, M, Salguero Bodes, Francisco, Everett, H, Brookes, S, Porter, E, MacLoughlin, R, Charleston, B , Subbarao, K, Townsend, A and Tchilian, E (2018) Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine Journal of Immunology, 200 (12). pp. 4068-4077.
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Official URL: http://www.jimmunol.org/
Abstract
Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication.
| Item Type: | Article | ||||||||||||||||||||||||||||||||||||||||||
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| Divisions : | Faculty of Health and Medical Sciences > School of Veterinary Medicine | ||||||||||||||||||||||||||||||||||||||||||
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| Date : | 27 April 2018 | ||||||||||||||||||||||||||||||||||||||||||
| Funders : | BBSRC | ||||||||||||||||||||||||||||||||||||||||||
| DOI : | 10.4049/jimmunol.1800142 | ||||||||||||||||||||||||||||||||||||||||||
| Copyright Disclaimer : | Copyright 2018 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license. | ||||||||||||||||||||||||||||||||||||||||||
| Depositing User : | Melanie Hughes | ||||||||||||||||||||||||||||||||||||||||||
| Date Deposited : | 11 Apr 2018 11:04 | ||||||||||||||||||||||||||||||||||||||||||
| Last Modified : | 11 Dec 2018 11:24 | ||||||||||||||||||||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/846173 |
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