Oleanane Triterpenoids from the Algerian Salvia phlomoides

Benniou, L, Langat, Moses, Mulholland, Dulcie, Benayache, F and Benayache, S (2018) Oleanane Triterpenoids from the Algerian Salvia phlomoides Phytochemistry Letters, 24. pp. 136-139.

Text Oleanane Triterpenoids from the Algerian Salvia phlomoides.docx - Accepted version Manuscript Download (68kB)

Abstract

Three previously unreported triterpenoids 2α,3β,11α-trihydroxyolean-18-ene 1, 3β-acetoxy,2α,11α- dihydroxyolean-18-ene 2 and 2α-acetoxy,3β,11α-dihydroxyolean-18-ene 3 were isolated from the chloroform extract of aerial parts (leaves and flowers) of Salvia phlomoides collected from the Constantine region in the east of Algeria. Structures were determined using NMR spectroscopy and HR-ESI mass spectrometry. Compounds 1, 2 and 3 were tested against the NCI panel of human tumour cell lines at a single dose of 10 µM. Compound 2 was the most active showing a 38 % growth inhibition against the leukemia RPMI-8226 line.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Chemistry
Authors :	Name Email ORCID Benniou, L Langat, Moses M.Langat@surrey.ac.uk Mulholland, Dulcie D.Mulholland@surrey.ac.uk Benayache, F Benayache, S
Date :	20 March 2018
DOI :	10.1016/j.phytol.2018.02.004
Copyright Disclaimer :	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords :	Lamiaceae, Salvia phlomoides, oleanane triterpenoids, cytotoxicity screening.
Depositing User :	Melanie Hughes
Date Deposited :	12 Feb 2018 11:26
Last Modified :	20 Mar 2019 02:08
URI:	http://epubs.surrey.ac.uk/id/eprint/845810

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