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Older Human B Cells and Antibodies

Dunn-Walters, Deborah and O’Hare, Joselli Silva (2017) Older Human B Cells and Antibodies In: Handbook of Immunosenescence. Springer International Publishing, pp. 1-34.

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B cells have a number of different roles in the immune response. Their excellent antigen presentation potential can contribute to the activation of other cells of the immune system, and evidence is emerging that specialized subsets of these cells, that may be increased with age, can influence the cell-mediated immune system in antitumor responses. They can also regulate immune responses, to avoid autoreactivity and excessive inflammation. Deficiencies in regulatory B cells may be beneficial in cancer but will only exacerbate the inflammatory environment that is a hallmark of aging. The B cell role as antibody producers is particularly important, since antibodies perform numerous different functions in different environments. Although studying tissue responses in humans is not as easy as in mice, we do know that certain classes of antibodies are more suited to protecting the mucosal tissues (IgA) or responding to T-independent bacterial polysaccharide antigens (IgG2) so we can make some inference with respect to tissue-specific immunity from a study of peripheral blood. We can also make inferences about changes in B cell development with age by looking at the repertoire of different B cell populations to see how age affects the selection events that would normally occur to avoid autoreactivity, or increase specificity, to antigen.

Item Type: Book Section
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
O’Hare, Joselli Silva
Editors :
Fulop, Tamas
Franceschi, Claudio
Hirokawa, Katsuiku
Pawelec, Graham
Date : 5 October 2017
DOI : 10.1007/978-3-319-64597-1_21-1
Copyright Disclaimer : © Springer International Publishing AG
Uncontrolled Keywords : Tolerance B cell repertoire, Autoantibodies, Immunoglobulin genes, Age-related B cells, Aging, Antibody class switching, Affinity maturation, Regulatory B cells, Humoral immunity
Depositing User : Karen Garland
Date Deposited : 11 Jan 2018 14:33
Last Modified : 16 Jan 2019 19:06

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