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In vitro Studies.

Velliou, Eirini, Pefani, E, Brito dos Santos, S, Fuentes-Gari, M, Misener, R, Panoskaltsis, N, Mantalaris, A, Georgiadis, MC and Pistikopoulos, EN (2017) In vitro Studies. In: Modelling Optimization and Control of Biomedical Systems. Wiley, pp. 233-264. ISBN 978-1-118-96559-7

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This chapter describes human normal and abnormal (i.e., so-called leukaemia) haematopoiesis, the latter being a severe cancer of the blood. It analyses the process of haematopoiesis – normal and abnormal – as well as the bone marrow (BM) architecture and the cell cycle procedure. Moreover, the chapter discusses current experimental platforms for studying leukaemia ex vivo and parameters that have to be taken into consideration when designing a treatment protocol (i.e., chemotherapy). A first step towards understanding and optimising chemotherapy for acute myeloid leukaemia (AML) treatment is the conduction of in vitro studies that aim at the reproduction of the in vivo environment. A variety of chemotherapy drugs are generally used, depending on the type of leukaemia. The most commonly used drugs for treatment of leukaemia are cytarabine (cytosine arabinose [ara-C]), and the anthracycline drugs.

Item Type: Book Section
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Pefani, E
Brito dos Santos, S
Fuentes-Gari, M
Misener, R
Panoskaltsis, N
Mantalaris, A
Georgiadis, MC
Pistikopoulos, EN
Editors :
Pistikopoulos, EN
Naşcu, I
Date : 29 December 2017
DOI : 10.1002/9781118965580.ch7
Copyright Disclaimer : Copyright 2018 John Wiley & Sons Ltd.
Uncontrolled Keywords : acute myeloid leukaemia treatment; anthracycline drugs; bone marrow architecture; cell cycle procedure; chemotherapy; cytarabine; human haematopoietic system; in vitro studies
Depositing User : Melanie Hughes
Date Deposited : 23 Nov 2017 14:33
Last Modified : 16 Jan 2019 19:04

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