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Salmonella vaccination in pigs: a review

Wales, Andrew and Davies, RH (2016) Salmonella vaccination in pigs: a review Zoonoses and Public Health, 64 (1). pp. 1-13.

25 Zoonoses Public Health (2017) 64, 1-13.pdf - Accepted version Manuscript

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The control of Salmonella enterica in pig production is necessary for both public and animal health. The persistent and frequently asymptomatic nature of porcine Salmonella infection and the organism's abilities to colonize other animal species and to survive in the environment mean that effective control generally requires multiple measures. Vaccination is one such measure, and the present review considers its role and its future, drawing on studies in pigs from the 1950s to the present day. Once established in the body as an intracellular infectious agent, Salmonella can evade humoral immunity, which goes some way to explaining the often disappointing performance of inactivated Salmonella vaccines. More recent approaches, using mucosal presentation of antigens, live vaccines and adjuvants to enhance cell-mediated immunity, have met with more success. Vaccination strategies that involve stimulating both passive immunity from the dam plus active immunity in offspring appear to be most efficacious, although either approach alone can yield significant control of Salmonella. Problems that remain include relatively poor control of Salmonella serovars that are dissimilar to the vaccine antigen mix, and difficulties in measuring and predicting the performance of candidate vaccines in ways that are highly relevant to their likely use in commercial production.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Davies, RH
Date : 8 February 2016
DOI : 10.1111/zph.12256
Copyright Disclaimer : This is the peer reviewed version of the following article: Wales, A. D. and Davies, R. H. (2017), Salmonella Vaccination in Pigs: A Review. Zoonoses Public Health, 64: 1–13. doi:10.1111/zph.12256, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords : Salmonella spp, swine, zoonoses, foodborne pathogens, preventive medicine
Depositing User : Melanie Hughes
Date Deposited : 18 Oct 2017 15:31
Last Modified : 24 Oct 2017 12:05

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