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Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Lophatananon, Artitaya, Stewart-Brown, Sarah, Kote-Jarai, Zsofia, Olama, Ali Amin Al, Garcia, Sara Benlloch, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Giles, Graham G, Fitzgerald, Liesel M , Southey, Melissa C, Pharoah, Paul, Pashayan, Nora, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Stanford, Janet L, Brenner, Hermann, Dieffenbach, Aida K, Arndt, Volker, Park, Jong Y, Lin, Hui-Yi, Sellers, Thomas, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A, Schleutker, Johanna, Nordestgaard, BØrge G, Wiklund, Fredrik, Travis, Ruth C, Haiman, Christopher A, Thibodeau, Stephen N, Maier, Christiane, Walther, Vogel, Blot, William J, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Pandha, Hardev, Teixeira, Manuel R, Cook, Margaret, Govindasami, Koveela, Guy, Michelle, Leongamornlert, Daniel, Sawyer, Emma J, Wilkinson, Rosemary, Morgan, Angela, Fisher, Cyril, Saunders, Edward J, Tymrakiewicz, Malgorzata, Livni, Naomi, Hazel, Steve, Dadaev, Tokhir, Cox, Angela, George, Anne, Lane, Athene, Marsden, Gemma, Davis, Michael, Brown, Paul, Pedersen, John, Hopper, John L, Karlsson, Ami, Cavalli-Bjoerkman, Carin, Adolfson, Jan, Johansson, Jan-Erik, Broms, Michael, Stattin, Paer, Kolb, Suzanne, Stegmaier, Christa, Zachariah, Babu, Park, Hyun, Haley, James, Pow-Sang, Julio, Rincon, Maria, Radlein, Selina, Vlahova, Aleksandrina, Mitkova, Atanaska, Kachakova, Darina, Popov, Elenko, Christova, Svetlana, Dikov, Tihomir, Eckert, Allison, Collins, Angus, Wood, Glenn, Malone, Greg, Alexander, Kimberly, Kerr, Kris, Kedda, Mary-Anne, Turner, Megan, Saunders, Pamela, Heathcote, Peter, Srinivasan, Srilakshmi, Omara, Tracy, Yeadon, Trina, Lose, Felicity, Easton, Douglas, Eeles, Rosalind A and Muir, Kenneth (2017) Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium British Journal of Cancer, 117 (5). pp. 734-743.

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Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height 4180cm are at a 22% increased risk as compared to men with height o173cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.

Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Lophatananon, Artitaya
Stewart-Brown, Sarah
Kote-Jarai, Zsofia
Olama, Ali Amin Al
Garcia, Sara Benlloch
Neal, David E
Hamdy, Freddie C
Donovan, Jenny L
Giles, Graham G
Fitzgerald, Liesel M
Southey, Melissa C
Pharoah, Paul
Pashayan, Nora
Gronberg, Henrik
Wiklund, Fredrik
Aly, Markus
Stanford, Janet L
Brenner, Hermann
Dieffenbach, Aida K
Arndt, Volker
Park, Jong Y
Lin, Hui-Yi
Sellers, Thomas
Slavov, Chavdar
Kaneva, Radka
Mitev, Vanio
Batra, Jyotsna
Spurdle, Amanda
Clements, Judith A
Schleutker, Johanna
Nordestgaard, BØrge G
Wiklund, Fredrik
Travis, Ruth C
Haiman, Christopher A
Thibodeau, Stephen N
Maier, Christiane
Walther, Vogel
Blot, William J
Kibel, Adam S
Cybulski, Cezary
Cannon-Albright, Lisa
Teixeira, Manuel R
Cook, Margaret
Govindasami, Koveela
Guy, Michelle
Leongamornlert, Daniel
Sawyer, Emma J
Wilkinson, Rosemary
Morgan, Angela
Fisher, Cyril
Saunders, Edward J
Tymrakiewicz, Malgorzata
Livni, Naomi
Hazel, Steve
Dadaev, Tokhir
Cox, Angela
George, Anne
Lane, Athene
Marsden, Gemma
Davis, Michael
Brown, Paul
Pedersen, John
Hopper, John L
Karlsson, Ami
Cavalli-Bjoerkman, Carin
Adolfson, Jan
Johansson, Jan-Erik
Broms, Michael
Stattin, Paer
Kolb, Suzanne
Stegmaier, Christa
Zachariah, Babu
Park, Hyun
Haley, James
Pow-Sang, Julio
Rincon, Maria
Radlein, Selina
Vlahova, Aleksandrina
Mitkova, Atanaska
Kachakova, Darina
Popov, Elenko
Christova, Svetlana
Dikov, Tihomir
Eckert, Allison
Collins, Angus
Wood, Glenn
Malone, Greg
Alexander, Kimberly
Kerr, Kris
Kedda, Mary-Anne
Turner, Megan
Saunders, Pamela
Heathcote, Peter
Srinivasan, Srilakshmi
Omara, Tracy
Yeadon, Trina
Lose, Felicity
Easton, Douglas
Eeles, Rosalind A
Muir, Kenneth
Date : 1 August 2017
DOI : 10.1038/bjc.2017.231
Copyright Disclaimer : © The Author(s) named above, 2017. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit
Uncontrolled Keywords : Height; SNPs; Gene and environment interaction; Prostate cancer
Depositing User : Clive Harris
Date Deposited : 13 Sep 2017 11:39
Last Modified : 16 Jan 2019 18:56

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