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UK Pigs at the Time of Slaughter: Investigation into the Correlation of Infection with PRRSV and HEV

Frossard, Jean-Pierre, Grierson, Sylvia, Cheney, Tanya, Steinbach, Falko, Choudhury, Bhudipa and Williamson, Susanna (2017) UK Pigs at the Time of Slaughter: Investigation into the Correlation of Infection with PRRSV and HEV Viruses, 9 (6).

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Hepatitis E virus (HEV) and porcine reproductive and respiratory syndrome virus (PRRSV) and are both globally prevalent in the pig population. While HEV does not cause clinical disease in pigs, its zoonotic potential has raised concerns in the food safety sector. PRRS has become endemic in the United Kingdom (UK) since its introduction in 1991, and continues to cause considerable economic losses to the swine industry. A better understanding of the current prevalence and diversity of PRRSV and HEV in the UK, and their potential association, is needed to assess risks and target control measures appropriately. This study used plasma, tonsil, and cecal content samples previously collected from pigs in 14 abattoirs in England and Northern Ireland to study the prevalence of several pathogens including PRRSV and HEV. The diversity of PRRSV strains detected in these samples was analyzed by sequencing open reading frame 5 (ORF5), revealing no substantial difference in PRRSV strains from these clinically unaffected pigs relative to those from clinical cases of disease in the UK. Despite the potential immuno-modulatory effect of PRRSV infection, previously demonstrated to affect Salmonella and HEV shedding profiles, no significant association was found between positive PRRSV status and positive HEV status.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Frossard, Jean-Pierre
Grierson, Sylvia
Cheney, Tanya
Choudhury, Bhudipa
Williamson, Susanna
Date : 9 June 2017
DOI : 10.3390/v9060110
Copyright Disclaimer : © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (
Uncontrolled Keywords : Porcine viruses; PRRSV; HEV; Evolution and molecular epidemiology; Co-infections
Depositing User : Clive Harris
Date Deposited : 30 Aug 2017 13:51
Last Modified : 16 Jan 2019 18:55

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