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Diterpenoids from the Roots of Croton dichogamus Pax

Aldhaher, A, Langat, Moses, Ndunda, B, Chirchir, D, Midiwo, JO, Njue, A, Schwikkard, S, Carew, M and Mulholland, Dulcie (2017) Diterpenoids from the Roots of Croton dichogamus Pax Phytochemistry, 144. pp. 1-8.

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Four previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus. Compounds were tested at one concentration, 1x10-5 M, in the NCI59 cell one-dose screen but did not show significant activity snd were also evaluated for their cytotoxicity against Caco-2 cell lines using the neutral red assay. 10-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 µM, with values of decreased viability of 28%, 48% and 43% respectively. None of the other tested compounds showed significant activity.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Aldhaher, A
Ndunda, B
Chirchir, D
Midiwo, JO
Njue, A
Schwikkard, S
Carew, M
Date : 1 September 2017
DOI : 10.1016/j.phytochem.2017.08.014
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Croton dichogamus, Euphorbiaceae, crotofolane, crotodichogamoin B, crothalimene A, crothalimene B, patchoulane, Caco-2 cell viability
Depositing User : Melanie Hughes
Date Deposited : 25 Aug 2017 10:42
Last Modified : 01 Sep 2018 02:08

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